Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth

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Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth

Hepatocellular carcinoma (HCC), frequently seen in patients with liver cirrhosis caused by alcohol abuse or chronic viral hepatitis, is the most common form of liver cancer worldwide. As such, it is the third-most common cause of cancer-related death and has a notoriously poor prognosis. At present, surgery is the most effective treatment for HCC, but is only successful in the 10%–20% of cases where cancer cells have not spread beyond the liver.

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