Link between driver of ovarian cancer and metabolism opens up new therapeutic strategies
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11 January 2021Link between driver of ovarian cancer and metabolism opens up new therapeutic strategies
Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer. Researchers also showed that pharmacologic inhibition of glutamine metabolism may represent an effective therapeutic strategy for ARID1A-mutant ovarian cancer.
