Just a few millimeters thick, articular cartilage plays a crucial role in our musculoskeletal system, since it is responsible for smooth (in the truest sense of the word) movement. However, the downside of its particular structure is that even minor injuries do not regenerate. Timely treatment of cartilage damage is therefore essential. Biomaterials are often used to support the cells, their distribution and protection. In most cases, this treatment significantly improves the patient’s clinical symptoms but fails to fully restore the cartilage to its original state. The working group led by Sylvia Nürnberger (MedUni Vienna’s Department of Orthopedics and Trauma Surgery) develops strategies for regeneration and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration.