Identification of Oligo-DNA that promotes skeletal muscle differentiation

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Identification of Oligo-DNA that promotes skeletal muscle differentiation

Skeletal muscle is the largest tissue in the human body and is responsible not only for locomotion but for energy metabolism and heat production. Age-related muscle atrophy reduces motor function and contributes to the need for nursing care. In addition, muscle atrophy associated with various chronic diseases is known to be a risk factor for life expectancy. Myoblasts, the progenitor cells of muscle, play an important role in maintaining muscle homeostasis. However, it has been reported that the differentiation ability of myoblasts decreases with age and disease, and this is thought to be one of the causes of muscle atrophy. In order to prevent or treat muscle atrophy, a research team led by Assistant Professor Tomohide Takaya of Shinshu University, Faculty of Agriculture studied molecules that promote myoblast differentiation.

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