Swelling of lymph nodes in the armpit area is a normal response to COVID-19 vaccinations, but when they are seen on mammograms, they can be mistaken for nodes that are swollen because of cancer. In some cases, the nodes are biopsied to confirm they are not cancer. To avoid confusion by patients and their providers, and to avoid delays in either vaccinations or recommended mammograms through the pandemic, radiologists at Massachusetts General Hospital (MGH) have published an approach to manage what is expected to be a fairly common occurrence as vaccination programs ramp up. The approach is described in the American Journal of Roentgenology.