Research team profiles histone mutational landscape of human cancers

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Research team profiles histone mutational landscape of human cancers

Researchers in the Muir Lab at Princeton University’s Department of Chemistry have completed the first comprehensive analysis of cancer-associated histone mutations in the human genome, featuring both biochemical and cellular characterizations of these substrates. Their study reports that histone mutations that perturb nucleosome remodeling may contribute to the development or progression of a wide range of human cancers.

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