There are 1.5 million cases of drug-induced kidney toxicity each year in the U.S. Among the usual suspects are cyclosporin and cisplatin, a pair of widely used chemotherapy drugs. Because both are considered lifesaving therapies, research into mitigating the kidney damage they cause is vital to improving treatment for cancer patients. Using a kidney-specific tissue-on-a-chip technology, researchers from Grass Center for Bioengineering at The Hebrew University of Jerusalem and the biotech company Tissue Dynamics have uncovered the mechanism that causes kidney damage from these drugs, as well as a treatment to prevent or reverse nephrotoxicity. The findings are published in Science Translational Medicine.