Many diseases affect different vessels in our body, such as blood vessels, bile ducts or airways. Visualizing these in animal models of disease, to better understand what is actually going wrong form a structural point of view has been an area of intense research. We developed a new method, independent of antibodies or microscopes, to visualize multiple vessels at the same time in a mouse model for a human disease known as Alagille syndrome. This new technique allows us to see, measure, and precisely define organ architecture—transforming our understanding of this disease, and the regenerative process that occurs in some patients, and in some of the mice.