A reproducibility crisis is ongoing in scientific research, where many studies may be difficult or impossible to replicate and thereby validate, especially when the study involves a very large sample size. For example, to evaluate the validity of a high-throughput genetic study’s findings scientists must be able to replicate the study and achieve the same results. Now researchers at Penn State and the University of Minnesota have developed a statistical tool that can accurately estimate the replicability of a study, thus eliminating the need to duplicate the work and effectively mitigating the reproducibility crisis.