Novel cancer vaccine targets oncogenes known to evade immunity in melanoma and neuroblastoma models

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Novel cancer vaccine targets oncogenes known to evade immunity in melanoma and neuroblastoma models

A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study for neuroblastoma and melanoma. The neuroblastoma model showed a 75% cure with long-term survival, researchers at Children’s National Hospital found.

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