With nearly a quarter of the U.S. population vaccinated and vaccines continuing to roll out across the country, Americans are eagerly anticipating an end to the coronavirus pandemic. For insights about what the end of the COVID-19 pandemic might look like, the Public Health On Call podcast recently spoke with Graham Mooney and Jeremy Greene, faculty members in the Department of the History of Medicine at the Johns Hopkins School of Medicine. Together, they discuss what history tells us about how past pandemics resolved, the origins of vaccine hesitancy, and what might set this pandemic apart from the ones that came before it.