It has long been known that obesity is an inflammatory disease, i.e. a chronic defensive reaction of the body to stress caused by excess nutrients. Based on this knowledge, a group of researchers led by Nabil Djouder, head of the Growth Factors, Nutrients and Cancer Group at the Spanish National Cancer Research Centre (CNIO), decided to try to fight obesity by preventing inflammation—and they succeeded. Their paper, published this week in Nature Metabolism, shows that digoxin, a drug already in use against heart diseases, reduces inflammation and leads to a 40% weight loss in obese mice, without any side effects.