Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett’s esophagus. Barrett’s esophagus is characterized by the replacement of the keratinocytes by columnar cells in the lower esophagus upon chronic acid reflux. This metaplasia is considered a precancerous lesion that increases by around 50 times the risk of this oesophageal adenocarcinoma. Nonetheless, the mechanisms involved in the development of metaplasia in the esophagus are still partially unknown.