Researchers from Niigata University , the University of Tokyo, Osaka University and Tokyo Medical University, Japan, have developed a new approach that could revolutionize the treatment, prevention, and possibly reversal of the damage caused by liver diseases. This novel strategy exploits small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs).