A team of researchers from the University of Oxford, Simon Fraser University and Genomics PLC, has conducted a genome-wide association study using the 2020 UK Biobank data release, using almost triple the discovery sample size of previous efforts. In their paper published in the journal Nature Neuroscience, the group describes using the UK Biobank to examine the association of common variants to 3,935 image-derived phenotypes (IDPs). Nana Matoba and Jason Stein with the University of North Carolina at Chapel Hill have published a News & Views piece in the same journal issue outlining some of the issues involved in using both MRI imaging and genetic association studies to identify neural disorders and also discuss the work done by the team on this new effort.