Molecular alteration may be cause—not consequence—of heart failure
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13 May 2021Molecular alteration may be cause—not consequence—of heart failure
Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
