Gene therapy boosts Parkinson’s disease drug benefits
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3 November 2021Gene therapy boosts Parkinson’s disease drug benefits
In late-stage Parkinson’s disease, the drug levodopa becomes less effective in treating symptoms because of the inexorable loss of dopamine-releasing neurons. But a new Northwestern Medicine preclinical study shows a gene therapy targeting the small brain region where these neurons reside, the substantia nigra, substantially boosts the benefits of levodopa.
