Pain neuron-derived peptide prevents endotoxic death by targeting kynurenine pathway in microglia

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Pain neuron-derived peptide prevents endotoxic death by targeting kynurenine pathway in microglia

A research team led by the National Institute for Physiological Sciences and joined by Hokkaido University explored the role of pain neurons in the regulation of endotoxic death. They found that peptide named Reg3γ acts as a pain neuron-enriched brain-targeted hormone that protects the host from endotoxic death.

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