Illumination of immune checkpoint LAG3 ‘black box’ could yield new cancer and autoimmune therapies
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18 April 2022Illumination of immune checkpoint LAG3 ‘black box’ could yield new cancer and autoimmune therapies
Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can become exhausted, or unable to function properly. One immunotherapy that revitalizes these cells by blocking an immune checkpoint protein called LAG3 was recently approved by federal regulators. But exactly how LAG3 works has remained a mystery—until now.
