The current monkeypox outbreak is more widespread than previous outbreaks outside of Africa and should prompt all clinicians to be attuned to the possibility that patients presenting with febrile illness and rash may be infected, according to the authors of a new commentary from the Johns Hopkins Center for Health Security at the Bloomberg School of Public Health. The authors also note that a significant number of these new cases have occurred among men who have sex with men (MSM), though the cause is unclear. These and other important facts about the current monkeypox outbreak are explained in a new commentary published in Annals of Internal Medicine.