Bone tissue homeostasis is maintained by a balance between bone formation by osteoblasts and bone resorption by osteoclasts. However, when osteoblast function declines with age, bone remodeling becomes out of balance, bone mass and density decrease, and osteoporosis occurs, affecting 200 million people around the world. Molecules that activate osteoblasts and promote bone differentiation are thought to be drug discovery seeds for osteoporosis.