The most common form of liver disease, alcohol-associated liver disease (ALD), contributes to half a million cirrhosis deaths worldwide annually. Odds of survival are very low and treatment options are limited. Two manifestations of ALD have a particularly poor prognosis: alcohol-associated hepatitis (AH) and alcohol-associated cirrhosis (AC). A team of researchers investigating the underlying causes of AH and AC observed significant alterations in multiple proteins involved in various biological processes in both diseases that may serve as biomarkers or treatment targets. Their research and dataset appear in the American Journal of Pathology.