While some diseases and disorders can be easily attributed to specific genetic mutations, for many diseases—especially neuropsychiatric ones—the causes are much more complicated, influenced by both genetic and environmental factors. A new study at the University of Chicago examined data from over 400,000 individuals to better understand how those two factors play into the variations seen in a number of neuropsychiatric disorders, with the hope of eventually identifying ways that individuals who are at risk can modify their environments to protect their mental health. The research was published on September 6 in Cell Reports Medicine.