Mount Sinai researchers have used novel artificial intelligence methods to examine structural and cellular features of human brain tissues to help determine the causes of Alzheimer’s disease and other related disorders. The research team found that studying the causes of cognitive impairment by using an unbiased AI-based method—as opposed to traditional markers such as amyloid plaques—revealed unexpected microscopic abnormalities that can predict the presence of cognitive impairment. These findings were published in the journal Acta Neuropathologica Communications on September 20.