Experts call for radical global action to end stigma and discrimination against people with mental health conditions, as this is often “worse than the condition itself.” The new “Lancet Commission on Ending Stigma and Discrimination in Mental Health,” co-chaired by Professor Sir Graham Thornicroft, is the result of work by more than 50 experts, including experts by experience from across the world. The report finds that people with lived experience of mental health conditions must be empowered and supported to play active an central roles in stigma reduction efforts.