Anti-cancer immune cells are critical to inhibiting the development and progression of tumors, and deregulation of the immune system can limit the ability of immune cells to identify and target cancer cells for destruction. Cancer cells are also subjected to various environmental stresses that impact their survival, such as nutrient deprivation, low oxygen levels and anti-cancer treatments. To continue to survive and overcome these stresses, cancer cells activate survival signaling pathways. PERK is a protein that is activated during stress-induced signaling, but how PERK activation in cancer cells contributes to immune cell evasion is unknown.